The term mucoadhesion is used specifically when the bond involves mucous coating and an adhesive polymeric device, while cytoadhesion is the cell-specific bioadhesion. The amoxicillin mucoadhesive microspheres, potassium clavulanate mucoadhesive microspheres were prepared by an emulsification/evaporation method. Microspheres were investigated using scanning electron microscopy. The polymer ratio, stirring speed and the temperature affected the particle size, shape and surface morphology of the microspheres. In-vitro release studies were carried out in pH 1.2 HCl buffer medium. Drug release rate was tested on all prepared formulations and marketed product Augmentin-375 (Amoxicillin trihydrate 250 mg + Potassium Clavulanate 125 mg) using basket apparatus on a dissolution apparatus. The test conditions were as follows: marketed tablet and microspheres containing 100 mg of drug were placed in baskets in a vessel containing 900 ml of pH 1.2 HCl buffer medium with the temperature maintained at 37±0.5°C. The rotating rate of the basket was adjusted to 100 rpm. At different intervals, 5 ml of samples were withdrawn and filtered through a whatman’s filter paper. The equivalent volume of the medium with the same temperature was added to the dissolution vessel. The absorbance values of the filtrate at the wavelength of 272 nm for amoxicillin and 205 for potassium clavulanate were determined after suitable dilution. The maximum yield was found to be 78.92% for Amox F-I and 80.89% for Clav F-I. FT-IR spectra of formulated microspheres revealed the drug was compatible with the polymers in the processing conditions.
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